The free radical spin trap α-phenyl-tert-butyl nitrone attenuates the cerebral response to deep hypothermic ischemia
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چکیده
منابع مشابه
Reactivities of Substituted α-Phenyl-N-tert-butyl Nitrones
In this work, a series of α-phenyl-N-tert-butyl nitrones bearing one, two, or three substituents on the tert-butyl group was synthesized. Cyclic voltammetry (CV) was used to investigate their electrochemical properties and showed a more pronounced substituent effect for oxidation than for reduction. Rate constants of superoxide radical (O2(•-)) reactions with nitrones were determined using a UV...
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C-Phenyl N-tert-Butyl [15N]nitrone, Nitrone, Spin Trap, EPR Spin Trapping, Aminoxyl (Nitroxide) As compared to normal PBN, about fifty percent increase of electron paramagnetic reso nance (EPR) spin trapping sensitivity has been gained by using a new 100% 1:>N-enriched spin trap, C-phenyl /V-rm-butyl[15N]nitrone (PBN-15N). PBN-15N has been prepared by a convenient four-step route using ammoniu...
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The title mol-ecule, C(21)H(26)O(3), has a six-membered planar carbon ring as the central core, substituted at position 1 with phen-oxy-carbonyl, at position 2 with hy-droxy and at positions 3 and 5 with tert-butyl groups. The structure shows two independent but very similar mol-ecules within the asymmetric unit. For both independent mol-ecules, the ester carboxyl-ate group is coplanar with the...
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Electron Paramagnetic Resonance, Spin Trapping, Free Radicals N-[tert-13C]Butyl C-phenyl nitrone (PBN-[tert-13C]) has been synthesized for an EPR spin trapping competition study. The newly synthesized PBN-[tert-13C] shows different 13C-hyperfine splitting constants (a13C) when it traps free radicals as compared to another 13C-labeled PBN analogue, N-tert-butyl C-phenyl [nitronyl-13C]nitrone (PB...
متن کاملEPR Detection of the Superoxide Free Radical with the Nitrone Spin Traps DMPO and BMPO
acterizing free radicals in chemistry, biology and medicine, is detection by EPR spectroscopy. However, due to their high reactivity and short half-lives, direct EPR detection of many free radicals (e.g., superoxide, hydroxyl radical, alkyl radicals, etc.) is virtually impossible in solution at room temperature. Spin trapping is a technique developed in the late 1960s in which a nitrone or nitr...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2000
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(00)70186-3